PGT – Preimplantation Genetic Testing

  • Preimplantation Genetic Testing Aneuploidies (PGT-A)
  • Preimplantation Genetic Testing for Monogenic/Single Gene Disease (PGT-M)
  • Preimplantation Genetic Testing for Chromosomal Structural Rearrangement (PGT-SR)

Preimplantation Genetic Testing Aneuploidies (PGT-A)

Previously known as PGS, PGT-A is a technique used to analyze all 23 pairs of chromosomes. We use NGS (Next Generation Sequencing) as our PGT-A technique to detect genetic diseases caused by chromosomal disorders, such as Down syndrome, Patau syndrome and Edward syndrome.

Who should use PGT-A?

  • Couple with chromosome disorder
  • Couple with history of pregnancy with a child with a chromosome disorder
  • Couple where the woman is 35 years old or more
  • Couple with infertility problems and at least two failed embryo implantation

Preimplantation Genetic Testing for Monogenic/Single Gene Disease (PGT-M)

Previously known as PGD, PGT-M is a technique used to analyze genes in families with a known single gene disorder in which the gene and/or mutation has been confirmed.

Who should use PGT-M?

  • Family history of a genetic condition
  • One or both of couple are carrier of a known and confirmed single gene disorder
  • Couple have a child with a genetic disorder
  • Autosomal recessive condition (e.g. Alpha thalassemia, Beta thalassemia)
  • Autosomal dominant condition (e.g. Achondrophasia, Huntington disease)
  • X-linked monogenic (e.g. Duchene/Becker muscular dystrophy, Color blindness)

Preimplantation Genetic Testing for Chromosomal Structural Rearrangement (PGT-SR)

Reciprocal chromosome translocation is a form of chromosomal abnormality that occurs when a region from two or more chromosomes switched without adding or loosing genetic materials. Chromosome translocation carriers can produce unbalanced gametes that resulted in unbalanced embryos. PGT-SR is carried out to reduce miscarriage rate due to unbalanced chromosomes and increase the chance of successful pregnancy of euploid embryos.

Who should use PGT-SR?

  • Couple with a chromosomal translocation
  • Couple with a history of two or more miscarriages due to chromosomal disorders or unknown causes